Journal Publications

2018 | 2017 | 2016 | 2015 | 2014 | 2013 | 2012 | 2011 | 2010 | 2009 | 2008 | 2007 | 2006 | 2005 | 2004 | 2003 | 2002 | 2000 | 1999 | 1998 | 1997 | 1996 | 1995 | 1992


  1. Klein J, Lam WW, Czarnota, GJ and Stanisz GJ. Chemical exchange saturation transfer MRI to assess cell data in breast cancer xenografts at 7T. Oncotarget. 2018 9(59): 31490-31501.
  2. Gangeh MJ, Liu S, Tadayyon H, Czarnota GJ. Computer-Aided Theragnosis Based on Tumor Volumetric Information in Breast Cancer. IEEE Trans Ultrason Ferroelectr Freq Control. 2018 Aug;65(8):1359-1369. 
  3. O’Reilly MA, Chinnery T, Yee ML, Wu SK, Hynynen K, Kerbel RS, Czarnota GJ, Pritchard KI, Sahgal A. Preliminary Investigation of Focused Ultrasound-Facilitated Drug Delivery for the Treatment of Leptomeningeal Metastases. Sci Rep. 2018 Jun 13;8(1):9013
  4. El Kaffas A, Al-Mahrouki A, Hashim A, Law N, Giles A, Czarnota GJ. Role of Acid Sphingomyelinase and Ceramide in Mechano-Acoustic Enhancement of Tumor Radiation Responses. J Natl Cancer Inst. 2018. 110(9).
  5. Sannachi L, Gangeh M, Tadayyon H, Sadeghi-Naini A, Sonal Gandhi S, Wright FC, Slodkowska E, Curpen B, Tran WT, Czarnota GJ. Response monitoring of breast cancer patients receiving neoadjuvant chemotherapy using quantitative ultrasound, texture, and molecular features.PLoS One. 2018. 13(1): e0189634.
  6. El Kaffas A, Gangeh MJ, Farhat G, Tran WT, Hashim A, Giles A, Czarnota GJ. Tumour Vascular Shutdown and Cell Death Following Ultrasound-Microbubble Enhanced Radiation Therapy. Theranostics. 2018 Jan 1;8(2):314-327.
  7. Moore MJ, El-Rass S, Xiao Y, Wang Y, Wen XY, Kolios MC. Simultaneous ultra-high frequency photoacoustic microscopy and photoacoustic radiometry of zebrafish larvae in vivo. Photoacoustics. 2018 Sep 1;12:14-21.
  8. Fernandes DA, Kolios MC. Intrinsically absorbing photoacoustic and ultrasound contrast agents for cancer therapy and imaging. Nanotechnology. 2018 Dec 14;29(50):505103.
  9. Moore MJ, Strohm EM, Kolios MC. Triplex micron-resolution acoustic, photoacoustic, and optical transmission microscopy via photoacoustic radiometry. Opt Express. 2018 Aug 20;26(17):22315-22326.
  10. Bok TH, Hysi E, Kolios MC. In vitro photoacoustic spectroscopy of pulsatile blood flow: Probing the interrelationship between red blood cell aggregation and oxygen saturation. J Biophotonics. 2018 Aug;11(8):e201700300.



  1. Sadeghi-Naini A, Sannachi L, Tadayyon H, Tran WT, Slodkowska E, Trudeau M, Gandhi S, Pritchard K, Czarnota GJ.Chemotherapy-Response Monitoring of Breast Cancer Patients Using Quantitative Ultrasound-Based Intra-Tumour Heterogeneities Sci Rep. 2017 Sep 4;7(1):10352.
  2. Strohm EM, Wirtzfeld LA, Kolios MC, Czarnota GJ.   High frequency ultrasound imaging and simulations of sea urchin oocytes. J Am Stat Assoc. 2017. In Press.
  3. Al-Mahrouki A, Giles A, Hashim A, Kim HC, El-Falou A, Rowe-Magnus D, et al. (2017) Microbubble-based enhancement of radiation effect: Role of cell membrane ceramide metabolism. PLoS ONE 12(7): e0181951.
  4. Wirtzfeld L, Berndl ESL, Czarnota GJ, Kolios MC. Monitoring Quantitative Ultrasound Parameter Changes in a Cell Pellet Model of Cell Starvation. Biophys J. 2017.
  5. Tran WT, Gangeh MJ, Sannachi L, Chin L, Watkins E, Bruni SG, Rastegar RF, Curpen B, Trudeau M, Gandhi S, Yaffe M, Slodkowska E, Childs C, Sadeghi-Naini A, Czarnota GJ. Predicting breast cancer response to neoadjuvant chemotherapy using pretreatment diffuse optical spectroscopic texture analysis. Br J Cancer. 2017 May;116(10):1329-39.
  6. Tadayyon H, Sannachi L, Gangeh MJ, Kim C, Ghandi S, Trudeau M, Pritchard K, Tran WT, Slodkowska E, Sadeghi-Naini A, Czarnota GJ. A priori Prediction of Neoadjuvant Chemotherapy Response and Survival in Breast Cancer Patients using Quantitative Ultrasound. Sci Rep. 2017;7:45733.
  7. Pasternak M, Doss L, Farhat G, Al-Mahrouki A, Kim CH, Kolios M, Tran WT, Czarnota GJ. Effect of chromatin structure on quantitative ultrasound parameters. Oncotarget. 2017;8(12):19631-19644 .
  8. Mehrabian H, Desmond KL, Chavez S, Bailey C, Rola R, Sahgal A, Czarnota GJ, Soliman H, Martel AL, Stanisz GJ. Water Exchange Rate Constant as a Biomarker of Treatment Efficacy in Patients with Brain Metastases Undergoing Stereotactic Radiosurgery. Int J Radiat Oncol Biol Phys. 2017 Jan 10. pii: S0360-3016(17)30020-2. doi: 10.1016/j.ijrobp.2017.01.016.
  9. Bushehri A, Czarnota GJ, Zhang L, Hynynen K, Huang Y, Chan M, Chu W, Dennis K, Mougenot C, Coccagna J, Sahgal A, Chow E, DeAngelis C. Urinary cytokines/chemokines after magnetic resonance-guided high intensity focused ultrasound for palliative treatment of painful bone metastases. Ann Palliat Med. 2017 Jan;6(1):36-54 .
  10. Chan M, Dennis K, Huang Y, Mougenot C, Chow E, DeAngelis C, Coccagna J, Sahgal A, Hynynen K, Czarnota GJ, Chu W. Magnetic resonance-guided high intensity focused ultrasound for palliation of painful skeletal metastases – A pilot study. Technol Cancer Res Treat. 2016 Aug 1. pii: 1533034616658576.


  1. Gangeh MJ, Hashim A, Giles A, Sannachi L, Czarnota GJ. Computer Aided Prognosis for Cell Death Categorization and Prediction In vivo Using Quantitative Ultrasound and Machine Learning Techniques. [Epub ahead of print]. Medical Physics, vol. 43, no. 12, Dec. 2016.


  1. Pasternak MM, Sadeghi-Naini A, Ranieri SM, Giles A, Oelze ML, Kolios MC, Czarnota GJ. High-frequency ultrasound detection of cell death: Spectral differentiation of different forms of cell death in vitro. Oncoscience. [Epub ahead of print]. DOI: 10.18632/oncoscience.319


  1. Tran WT, Childs C, Chin L, Slodkowska E, Sannachi L, Tadayyon H, Watkins E, Wong SL, Curpen B, El Kaffas A, Al-Mahrouki A, Sadeghi-Naini A, Czarnota GJ. Multiparametric monitoring of chemotherapy treatment response in locally advanced breast cancer using quantitative ultrasound and diffuse optical spectroscopy. Oncotarget. 2016 Apr 12;7(15):19762-80 DOI: 10.18632/oncotarget.7844. PubMed PMID: 26942698. PubMed Central PMCID: PMC4991417.


  1. Lai P, Tarapacki C, Tran WT, El Kaffas A, Lee J, Hupple C, Iradji S, Giles A, Al-Mahrouki A, Czarnota GJ. Breast tumor response to ultrasound mediated excitation of microbubbles and radiation therapy in vivo. Oncoscience. 2016 Mar 24;3(3-4):98-108. DOI: 10.18632/oncoscience.299. PubMed PMID: 27226983. PubMed Central PMCID: PMC4872648.


  1. Tadayyon H, Sannachi L, Gangeh M, Sadeghi-Naini A, Tran W, Trudeau ME, Pritchard K, Ghandi S, Verma S, Czarnota GJ. Quantitative ultrasound assessment of breast tumor response to chemotherapy using a multi-parameter approach. Oncotarget. 2016 Apr 20. DOI: 10.18632/oncotarget.8862. PubMed PMID: 27105515.


  1. Gangeh MJ, Tadayyon H, Sannachi L, Sadeghi-Naini A, Tran WT, Czarnota GJ. Computer Aided Theragnosis Using Quantitative Ultrasound Spectroscopy and Maximum Mean Discrepancy in Locally Advanced Breast Cancer. IEEE Trans Med Imaging. 2016 Mar;35(3):778-90. DOI: 10.1109/TMI.2015.2495246. PubMed PMID: 26529750.


  1. Pasternak MM, Strohm EM, Berndl ES, Kolios MC. Properties of cells through life and death – an acoustic microscopy investigation. Cell Cycle.2015;14(18):2891-8. DOI: 10.1080/15384101.2015.1069925. PubMed PMID: 26178635 PubMed Central PMCID: PMC4825614.


  1. Fadhel MN, Kibria F, and Kolios MC. Photoacoustic spectral analysis to sense programmed erythrocyte cell death (eryptosis) for monitoring cancer response to treatment. Proc. SPIE 9708, Photons Plus Ultrasound: Imaging and Sensing 2016, 97080O (March 15, 2016). DOI: 10.1117/12.2211760


  1. Fadhel MN, Hysi E, Zalev J and Kolios MC. Photoacoustic simulation of microvessel bleeding: spectral analysis and its implication for monitoring vascular-targeted treatments. Proc. SPIE 9708, Photons Plus Ultrasound: Imaging and Sensing 2016, 97081B (March 15, 2016). DOI: 10.1117/12.2211774.


  1. Fadhel MN, Berndl ES, Strohm EM, Kolios MC. High-Frequency Acoustic Impedance Imaging of Cancer Cells. Ultrasound Med Biol. 2015 Oct;41(10):2700-13. DOI: 10.1016/j.ultrasmedbio.2015.06.003. PubMed PMID: 26166459.


  1. May JP, Hysi E, Wirtzfeld LA, Undzys E, Li SD, Kolios MC. Photoacoustic Imaging of Cancer Treatment Response: Early Detection of Therapeutic Effect from Thermosensitive Liposomes. PLoS ONE 2016 11(10): e0165345. DOI: 10.1371/journal.pone.0165345


  1. Moore MJ, Strohm EM, and Kolios MC . Assessment of the Nucleus-to-Cytoplasmic Ratio in MCF-7 Cells Using Ultra-high Frequency Ultrasound and Photoacoustics. Int J Thermophys 2016 37:118 DOI10.1007/s10765-016-2129-y


  1. Strohm EM, Moore MJ and Kolios MC. Acoustic and photoacoustic microscopy imaging of single leukocytes. Proc. SPIE 9708, Photons Plus Ultrasound: Imaging and Sensing 2016, 97082G (March 15, 2016). DOI:10.1117/12.2211759


  1. Moore MJ ; Strohm EM and Kolios MC. Simultaneous photoacoustic and optical attenuation imaging of single cells using photoacoustic microscopy. Proc. SPIE 9708, Photons Plus Ultrasound: Imaging and Sensing 2016, 970850 (March 15, 2016). DOI:10.1117/12.2212961


  1. Klein J, Czarnota G, Lam W, Tarapacki C, Stanisz G. In Vivo Measurements of CEST Magnetic Resonance Imaging Signal in Breast Cancer Xenografts at 7T. Int JRadiat Oncol Biol Phys. 2016 Oct 1;96(2S):E648. DOI:10.1016/j.ijrobp.2016.06.2251. PubMed PMID: 27675257.


  1. Tadayyon H, Sannachi L, Sadeghi-Naini A, Al-Mahrouki A, Tran WT, Kolios MC, Czarnota GJ. Quantification of Ultrasonic Scattering Properties of In Vivo Tumor Cell Death in Mouse Models of Breast Cancer. Transl Oncol. 2015 Dec;8(6):463-73. DOI: 10.1016/j.tranon.2015.11.001. PubMed PMID: 26692527; PubMed Central PMCID: PMC4701005.


  1. Sadeghi-Naini A, Zhou S, Gangeh MJ, Jahedmotlagh Z, Falou O, Ranieri S, Azrif M, Giles A, Czarnota GJ. Quantitative evaluation of cell death response in vitro and in vivo using conventional-frequency ultrasound. Oncoscience. 2015 Sep 3;2(8):716-26. PubMed PMID: 26425663; PubMed Central PMCID: PMC4580065.


  1. Sannachi L, Tadayyon H, Sadeghi-Naini A, Tran W, Gandhi S, Wright F, Oelze M, Czarnota G. Non-invasive evaluation of breast cancer response to chemotherapy using quantitative ultrasonic backscatter parameters. Med Image Anal. 2015 Feb;20(1):224-36. DOI: 10.1016/ PubMed PMID: 25534283.


  1. Sadeghi-Naini A, Vorauer E, Chin L, Falou O, Tran WT, Wright FC, Gandhi S, Yaffe MJ, Czarnota GJ. Early detection of chemotherapy-refractory patients by monitoring textural alterations in diffuse optical spectroscopic images. Med Phys. 2015 Nov;42(11):6130-46. DOI: 10.1118/1.4931603. PubMed PMID: 26520706.


  1. Al-Mahrouki AA, Wong E, Czarnota GJ. Ultrasound-stimulated microbubble enhancement of radiation treatments: endothelial cell function and mechanism. Oncoscience. 2015 Dec 15;2(12):944-57. PubMed PMID: 26909363. PubMed Central PMCID: PMC4741402.


  1. El Kaffas A, Sadeghi-Naini A, Falou O, Tran WT, Zhou S, Hashim A, Fernandes J, Giles A, Czarnota GJ. Assessment of tumor response to radiation and vascular targeting therapy in mice using quantitative ultrasound spectroscopy. Med Phys. 2015 Aug;42(8):4965-73. DOI: 10.1118/1.4926554. PubMed PMID: 26233222.


  1. Wirtzfeld LA, Berndl ES, Kolios MC. Ultrasonic Characterization of Extra-Cellular Matrix in Decellularized Murine Kidney and Liver. IEEE International Ultrasonics Symposium Proceedings 2015. DOI: 10.1109/ULTSYM.2015.0170


  1. Hysi E, May JP, Wirtzfeld L, Elijus Undyzs, Shyh-Dar Li, Kolios MC. Probing the in vivo changes in oxygen saturation with photoacoustic imaging as a non-invasive means of assessing treatment progression. Proc. of SPIE Vol. 9323, 93231Z DOI: 10.1117/12.2080372


  1. Muhannad Fadhel, and Kolios MC. Photoacoustic speckle and spectral analysis of vasculature trees. IFMBE Proceedings World Congress on Medical Physics and Biomedical Engineering Volume 51, 2015, Pages 1084-1087 DOI: 10.1007/978-3-319-19387-8_264


  1. Zalev J and Kolios MC. Exact solution for a photoacoustic wave from a finite-length cylindrical source. Journal of the Acoustical Society of America 137 (4), Pages: 1675–1682 DOI: 10.1121/1.4916273


  1. Moore MJ, Strohm EM, and Kolios MC. Evaluation of the Morphological Parameters of Cancer Cells Using High-Frequency Ultrasound and Photoacoustics. IEEE International Ultrasonics Symposium Proceedings. DOI:10.1109/ULTSYM.2015.0246


  1. Karmakar S, Hysi E, Kolios MC and Saha RK. Realistic photoacoustic image simulations of collections of solid spheres using linear array transducer. Proc. of SPIE Vol. 9323, 932339 DOI: 10.1117/12.2080794


  1. Nasr R, Falou O, Wirtzfeld L, Berndl E, and Kolios MC. Mean scatterer spacing estimation from pellets using cepstral analysis: A preliminary study. International Conference on Advances in Biomedical Engineering (ICABME) Article number 7323313, Pages 305-308 DOI: 10.1109/ICABME.2015.7323313


  1. Mehrabian H, Da Rosa M, Haider MA, Martel AL. Pharmacokinetic analysis of prostate cancer using independent component analysis. Magn Reson Imaging. 2015 Dec;33(10):1236-45. DOI: 10.1016/j.mri.2015.08.009. PubMed PMID: 26297961.


  1. Tadayyon H, Sadeghi-Naini A, Czarnota GJ. Noninvasive characterization of locally advanced breast cancer using textural analysis of quantitative ultrasound parametric images. Transl Oncol. 2014 Dec;7(6):759-67. DOI: 10.1016/j.tranon.2014.10.007. PubMed PMID: 25500086 PubMed Central PMCID: PMC4311023


  1. Sadeghi-Naini A, Sannachi L, Pritchard K, Trudeau M, Gandhi S, Wright FC, Zubovits J, Yaffe MJ, Kolios MC, Czarnota GJ. Early prediction of therapy responses and outcomes in breast cancer patients using quantitative ultrasound spectral texture. Oncotarget. 2014 Jun 15;5(11):3497-511. PubMed PMID: 24939867 PubMed Central PMCID: PMC4116498.


  1. Tadayyon H, Sadeghi-Naini A, Wirtzfeld L, Wright FC, Czarnota G. Quantitative ultrasound characterization of locally advanced breast cancer by estimation of its scatterer properties. Med Phys. 2014 Jan;41(1):012903. DOI: 10.1118/1.4852875. PubMed PMID: 24387530.


  1. Kim HC, Al-Mahrouki A, Gorjizadeh A, Sadeghi-Naini A, Karshafian R, Czarnota GJ. Quantitative ultrasound characterization of tumor cell death: ultrasound-stimulated microbubbles for radiation enhancement. PLoS One. 2014 Jul 22;9(7):e102343. DOI: 10.1371/journal.pone.0102343. PubMed PMID: 25051356. PubMed Central PMCID: PMC4106764.


  1. El Kaffas A, Nofiele J, Giles A, Cho S, Liu SK, Czarnota GJ. Dll4-notch signalling blockade synergizes combined ultrasound-stimulated microbubble and radiation therapy in human colon cancer xenografts. PLoS One. 2014 Apr 15;9(4):e93888. DOI: 10.1371/journal.pone.0093888. PubMed PMID: 24736631. PubMed Central PMCID: PMC3988033.


  1. Al-Mahrouki AA, Iradji S, Tran WT, Czarnota GJ. Cellular characterization of ultrasound stimulated microbubble radiation enhancement in a prostate cancer xenograft model. Dis Model Mech. 2014 Mar;7(3):363-72. DOI: 10.1242/dmm.012922. PubMed PMID: 24487407. PubMed Central PMCID: PMC3944496.


  1. El Kaffas A, Al-Mahrouki A, Tran WT, Giles A, Czarnota GJ. Sunitinib effects on the radiation response of endothelial and breast tumor cells. Microvasc Res. 2014 Mar; 92:1-9. DOI: 10.1016/j.mvr.2013.10.008. PubMed PMID: 24215790.



  1. Briggs K, Al Mahrouki A, Nofiele J, El-Falou A, Stanisz M, Kim HC, Kolios MC, Czarnota GJ. Non-invasive monitoring of ultrasound-stimulated microbubble radiation enhancement using photoacoustic imaging. Technol Cancer Res Treat. 2014 Oct;13(5):435-44. DOI: 10.7785/tcrtexpress.2013.600266. PubMed PMID: 24000993. PubMed Central PMCID: PMC4527466.


  1. Gangeh MJ, Sadeghi-Naini A, Diu M, Tadayyon H, Kamel MS, Czarnota GJ. Categorizing extent of tumor cell death response to cancer therapy using quantitative ultrasound spectroscopy and maximum mean discrepancy. IEEE Trans Med Imaging. 2014 Jun;33(6):1390-400. DOI: 10.1109/TMI.2014.2312254. PubMed PMID: 24893261.


  1. Nofiele JT, Czarnota GJ, Cheng HL. Noninvasive manganese-enhanced magnetic resonance imaging for early detection of breast cancer metastatic potential. Mol Imaging. 2014;13. DOI: 10.2310/7290.2013.00071. PubMed PMID: 24622809.


  1. Muhannad Fadhel, Berndl ES, Strohm E and Kolios MC. Ultra-High Frequency Acoustic Impedance Imaging of Cancer Cells, IEEE International Ultrasonics Symposium Proceedings. 2014 pp. 1912-1915


  1. Wirtzfeld LA, Berndl ES, Czarnota GJ and Kolios MC. Effective scatterer size estimates in HT- 29 spheroids at 55 MHz and 80 MHz. IEEE International Ultrasonics Symposium Proceedings. 2014 pp. 632-635


  1. Wirtzfeld LA, Berndl ES, Czarnota GJ and Kolios MC. Quantitative ultrasound analyses of cell starvation in HT-29 pellets. IEEE International Ultrasonics Symposium Proceedings. 2014 pp. 620-623


  1. Hysi E, May JP, Wirtzfeld L, Undzys E, Li SD, and Kolios MC. Longitudinal monitoring of oxygen saturation with photoacoustic imaging: An early, functional indicator of the in vivo efficacy of thermosensitive liposome treatments. IEEE International Ultrasonics Symposium Proceedings. 2014 pp. 357-360.


  1. Hysi E, Dopsa D, Kolios MC. Photoacoustic tissue characterization using envelope statistics and ultrasonic spectral parameters. Proc. of SPIE Vol. 8943, 89432E


  1. Desmond KL, Moosvi F, Stanisz GJ. Mapping of amide, amine, and aliphatic peaks in the CEST spectra of murine xenografts at 7 T. Magn Reson Med. 2014 May;71(5):1841-53. DOI: 10.1002/mrm.24822. PubMed PMID: 23801344.


  1. Bailey C, Moosvi F, Stanisz GJ. Mapping water exchange rates in rat tumor xenografts using the late-stage uptake following bolus injections of contrast agent. Magn Reson Med. 2013 Jun 25. doi: 10.1002/mrm.24847. [Epub ahead of print] PubMed PMID: 23801522.


  1. Kwok SJ, El Kaffas A, Lai P, Al-Mahrouki AA, Lee J, Iradji S, Tran WT, Giles A, Czarnota GJ. Ultrasound-mediated microbubble enhancement of radiation therapy studied using threedimensional high-frequency power Doppler ultrasound. Ultrasound Med Biol. 2013 Nov;39(11):1983-90. DOI:10.1016/j.ultrasmedbio.2013.03.025. PubMed PMID: 23993051.


  1. Sadeghi-Naini A, Papanicolau N, Falou O, Tadayyon H, Lee J, Zubovits J, Sadeghian A, Karshafian R, Al-Mahrouki A, Giles A, Kolios MC, Czarnota GJ. Low-frequency quantitative ultrasound imaging of cell death in vivo. Med Phys. 2013 Aug;40(8):082901. DOI: 10.1118/1.4812683. PubMed PMID: 23927356.


  1. Kim HC, Al-Mahrouki A, Gorjizadeh A, Karshafian R, Czarnota GJ. Effects of biophysical parameters in enhancing radiation responses of prostate tumors with ultrasound-stimulated microbubbles. Ultrasound Med Biol. 2013 Aug;39(8):1376-87. DOI: 10.1016/j.ultrasmedbio.2013.01.012. PubMed PMID: 23643061.


  1. Sadeghi-Naini A, Papanicolau N, Falou O, Zubovits J, Dent R, Verma S, Trudeau M, Boileau JF, Spayne J, Iradji S, Sofroni E, Lee J, Lemon-Wong S, Yaffe M, Kolios MC, Czarnota GJ. Quantitative ultrasound evaluation of tumor cell death response in locally advanced breast cancer patients receiving chemotherapy. Clin Cancer Res. 2013 Apr 15;19(8):2163-74. DOI: 10.1158/1078-0432.CCR-12-2965. PubMed PMID: 23426278.


  1. Falou O, Sadeghi-Naini A, Prematilake S, Sofroni E, Papanicolau N, Iradji S, Jahedmotlagh Z, Lemon-Wong S, Pignol JP, Rakovitch E, Zubovits J, Spayne J, Dent R, Trudeau M, Boileau JF, Wright FC, Yaffe MJ, Czarnota GJ. Evaluation of neoadjuvant chemotherapy response in women with locally advanced breast cancer using ultrasound elastography. Transl Oncol. 2013 Feb;6(1):17-24. PubMed PMID: 23418613. PubMed Central PMCID: PMC3573650.


  1. El Kaffas A, Giles A, Czarnota GJ. Dose-dependent response of tumor vasculature to radiation therapy in combination with Sunitinib depicted by three-dimensional high-frequency power Doppler ultrasound. Angiogenesis. 2013 Apr;16(2):443-54. DOI: 10.1007/s10456-012-9329-2. PubMed PMID: 23314761.


  1. Hysi E, Dopsa D, and Kolios MC. Photoacoustic radio-frequency spectroscopy (PA-RFS): A technique for monitoring absorber size and concentration. 2013 Proc. of SPIE Vol. 8581, 85813W


  1. El Kaffas A, Bekah D, Rui M, Kumaradas JC, and Kolios MC. Investigating longitudinal changes in the mechanical properties of MCF-7 cells exposed to paclitaxol using particle tracking microrheology. Physics in Medicine and Biology 58 (2013) 923–936.
  1. Pourebrahimi B, Al-Mahrouki AA, Zalev J, Nofiele JT, Czarnota GJ and Kolios MC. Classifying Normal and Abnormal Vascular Tissues using Photoacoustic Signals. Proc. of SPIE Vol. 8581, 858141


  1. Pourebrahimi, Yoon S, Dopsa D, Kolios MC. Improving the Quality of Photoacoustic Images using the Short-Lag Spatial Coherence Imaging Technique. Proc. of SPIE Vol. 8581, 85813Y


  1. Mehrabian H, Chopra R, Martel AL. Calculation of intravascular signal in dynamic contrast enhanced-MRI using adaptive complex independent component analysis. IEEE Trans Med Imaging. 2013 Apr;32(4):699-710. DOI: 10.1109/TMI.2012.2233747. PubMed PMID: 23247848.


  1. Bailey C, Desmond KL, Czarnota GJ, Stanisz GJ. Quantitative magnetization transfer studies of apoptotic cell death. Magn Reson Med. 2011 Jul;66(1):264-9. DOI: 10.1002/mrm.22820. PubMed PMID: 21695728.


  1. Sadeghi-Naini A, Falou O, Tadayyon H, Al-Mahrouki A, Tran W, Papanicolau N, Kolios MC, Czarnota GJ. Conventional frequency ultrasonic biomarkers of cancertreatment response in vivo. Transl Oncol. 2013 Jun 1;6(3):234-43. Print 2013 Jun. PubMed PMID: 23761215; PubMed Central PMCID: PMC3678128.


  1. Strohm EM, Berndl ES, Kolios MC. Probing red blood cell morphology using high-frequency photoacoustics. Biophys J. 2013 Jul 2;105(1):59-67. doi:10.1016/j.bpj.2013.05.037. PubMed PMID: 23823224; PubMed Central PMCID:PMC3699781.


  1. Pop M, Ghugre NR, Ramanan V, Morikawa L, Stanisz G, Dick AJ, Wright GA. Quantification of fibrosis in infarcted swine hearts by ex vivo late gadolinium-enhancement and diffusion-weighted MRI methods. Phys Med Biol. 2013 Aug 7;58(15):5009-28. doi: 10.1088/0031-9155/58/15/5009. Epub 2013 Jul 8. PubMed PMID: 23833042.
  1. Bock NA, Hashim E, Janik R, Konyer NB, Weiss M, Stanisz GJ, Turner R, Geyer S. Optimizing T1-weighted imaging of cortical myelin content at 3.0 T. Neuroimage. 2013 Jan 15;65:1-12. doi: 10.1016/j.neuroimage.2012.09.051. Epub 2012 Oct 1. PubMed PMID: 23036446.



  1. Al-Mahrouki AA, Karshafian R, Giles A, Czarnota GJ. Bioeffects of ultrasound-stimulated microbubbles on endothelial cells: gene expression changes associated with radiation enhancement in vitro. Ultrasound Med Biol. 2012 Nov;38(11):1958-69. DOI: 10.1016/j.ultrasmedbio.2012.07.009. PubMed PMID: 22980406.


  1. Falou O, Soliman H, Sadeghi-Naini A, Iradji S, Lemon-Wong S, Zubovits J, Spayne J, Dent R, Trudeau M, Boileau JF, Wright FC, Yaffe MJ, Czarnota GJ. Diffuse optical spectroscopy evaluation of treatment response in women with locally advanced breast cancer receiving neoadjuvant chemotherapy. Transl Oncol. 2012 Aug;5(4):238-46. PubMed PMID: 22937175. PubMed Central PMCID: PMC3431033.


  1.  Czarnota GJ, Karshafian R, Burns PN, Wong S, Al-Mahrouki A, Lee JW, Caissie A, Tran W, Kim C, Furukawa M, Wong E, Giles A. Tumor radiation response enhancement by acoustical stimulation of the vasculature. Proc Natl Acad Sci USA. 2012 Jul 24;109(30):E2033-41. DOI: 10.1073/pnas.1200053109. PubMed PMID: 22778441. PubMed Central PMCID: PMC3409730.


  1. Lee J, Karshafian R, Papanicolau N, Giles A, Kolios MC, Czarnota GJ. Quantitative ultrasound for the monitoring of novel microbubble and ultrasound radiosensitization. Ultrasound Med Biol. 2012 Jul;38(7):1212-21. DOI: 10.1016/j.ultrasmedbio.2012.01.028. PubMed PMID: 22579547.


  1. El Kaffas A, Tran W, Czarnota GJ. Vascular strategies for enhancing tumor response to radiation therapy. Technol Cancer Res Treat. 2012 Oct;11(5):421-32. PubMed PMID: 22568629.
  1. Dorożyński PP, Kulinowski P, Młynarczyk A, Stanisz GJ. MRI as a tool for evaluation of oral controlled release dosage forms. Drug Discov Today. 2012 Feb;17(3-4):110-23. doi: 10.1016/j.drudis.2011.10.026. Epub 2011 Nov 7. Review.PubMed PMID: 22094243.


  1. Shuhendler AJ, Staruch R, Oakden W, Gordijo CR, Rauth AM, Stanisz GJ, Chopra R, Wu XY. Thermally-triggered ‘off-on-off’ response of gadolinium-hydrogel-lipid hybrid nanoparticles defines a customizable temperature window for non-invasive magnetic resonance imaging thermometry. J Control Release. 2012 Feb 10;157(3):478-84. doi: 10.1016/j.jconrel.2011.09.061. Epub 2011 Sep 10. PubMed PMID: 21939700.


  1. Desmond KL, Stanisz GJ. Understanding quantitative pulsed CEST in the presence of MT. Magn Reson Med. 2012 Apr;67(4):979-90. doi: 10.1002/mrm.23074. Epub 2011 Aug 19. PubMed PMID: 21858864.


  1. Falou O, Sadeghi-Naini A, Soliman H, Yaffe MJ, Czarnota GJ. Diffuse optical imaging for monitoring treatment response in breast cancer patients. Conf Proc IEEE Eng Med Biol Soc. 2012;2012:3155-8. doi: 10.1109/EMBC.2012.6346634. PubMed PMID: 23366595.


  1. Sadeghi-Naini A, Falou O, Czarnota GJ. Quantitative ultrasound spectral parametric maps: early surrogates of cancer treatment response. Conf Proc IEEE Eng Med Biol Soc. 2012;2012:2672-5. doi: 10.1109/EMBC.2012.6346514. PubMed PMID:23366475.


  1. Sadeghi-Naini A, Falou O, Czarnota GJ. Quantitative ultrasound visualization of cell death: emerging clinical applications for detection of cancer treatment response. Conf Proc IEEE Eng Med Biol Soc. 2012;2012:1125-8. doi:10.1109/EMBC.2012.6346133. Review. PubMed PMID: 23366094.


  1. Miller DL, Smith NB, Bailey MR, Czarnota GJ, Hynynen K, Makin IR; Bioeffects Committee of the American Institute of Ultrasound in Medicine. Overview of therapeutic ultrasound applications and safety considerations. J Ultrasound Med. 2012 Apr;31(4):623-34. Review. PubMed PMID: 22441920.


  1. Hysi E, Saha RK, Kolios MC. Photoacoustic ultrasound spectroscopy for assessing red blood cell aggregation and oxygenation. J Biomed Opt. 2012 Dec;17(12):125006. doi: 10.1117/1.JBO.17.12.125006. PubMed PMID: 23235833.


  1. Strohm EM, Gorelikov I, Matsuura N, Kolios MC. Acoustic and photoacoustic characterization of micron-sized perfluorocarbon emulsions. J Biomed Opt. 2012 Sep;17(9):96016-1. doi: 10.1117/1.JBO.17.9.096016. PubMed PMID: 23085917.


  1. Hysi E, Saha RK, Kolios MC. On the use of photoacoustics to detect red blood cell aggregation. Biomed Opt Express. 2012 Sep 1;3(9):2326-38. Epub 2012 Aug 30. PubMed PMID: 23024924; PubMed Central PMCID: PMC3447572.


  1. Falou O, Jafari Sojahrood A, Kumaradas JC, Kolios MC. Surface modes and acoustic scattering of microspheres and ultrasound contrast agents. J Acoust Soc Am. 2012 Sep;132(3):1820-9. doi: 10.1121/1.4740505. PubMed PMID: 22978909.


  1. Austin JW, Kang CE, Baumann MD, DiDiodato L, Satkunendrarajah K, Wilson JR, Stanisz GJ, Shoichet MS, Fehlings MG. The effects of intrathecal injection of a hyaluronan-based hydrogel on inflammation, scarring and neurobehavioural outcomes in a rat model of severe spinal cord injury associated with arachnoiditis. Biomaterials. 2012 Jun;33(18):4555-64. doi: 10.1016/j.biomaterials.2012.03.022. Epub 2012 Mar 27. PubMed PMID: 22459192.3


  1. Chavez S, Stanisz GJ. A novel method for simultaneous 3D B(1) and T(1) mapping: the method of slopes (MoS). NMR Biomed. 2012 Sep;25(9):1043-55. doi:10.1002/nbm.2769. Epub 2012 Feb 26. PubMed PMID: 22368092.


  1. Flint JJ, Hansen B, Portnoy S, Lee CH, King MA, Fey M, Vincent F, Stanisz GJ, Vestergaard-Poulsen P, Blackband SJ. Magnetic resonance microscopy of human and porcine neurons and cellular processes. Neuroimage. 2012 Apr 2;60(2):1404-11. doi: 10.1016/j.neuroimage.2012.01.050. Epub 2012 Jan 14. PubMed PMID: 22281672; PubMed Central PMCID: PMC3304009.

  1. . Diffuse Optical Spectroscopy Evaluation of Treatment Response in Women with Locally Advanced Breast Cancer Receiving Neoadjuvant Chemotherapy O. Falou, H. Soliman, A. Sadeghi-Naini, S. Iradji, S. Lemon-Wong, J. Zubovits, J. Spayne, R. Dent, M. Trudeau, J. F. Boileau, F. C. Wright, M. J. Yaffe, and G. J. Czarnota, Translational Oncology, vol. 5, no. 4, pp. 238–246, 2012.
  1. . Lymphoepithelioma-like carcinoma of the breast: a diagnostic and therapeutic challenge R. Dinniwell, W. M. Hanna, M. Mashhour, R. S. Saad, and G. J. Czarnota, Current Oncology, vol. 19, no. 3, pp. e177–83, 2012 (2012)
  1. . On the use of photoacoustics to detect red blood cell aggregation Eno Hysi, Ratan K. Saha and Michael C. Kolios, Biomedical Optics Express, Vol. 3, No. 9, Pages 2326-2338 (2012)
  1. . Imaging innovations for cancer therapy response monitoring Ali Sadeghi-Naini, Omar Falou, John M Hudson, Colleen Bailey, Peter N Burns, Martin J Yaffe, Greg J Stanisz, Michael C Kolios & Gregory J Czarnota (2012) 
Imaging in Medicine, Voume 4 Number 3, Pages  311-327
  1. . Quantitative Ultrasound for the Monitoring of Novel Microbubble and Ultrasound Radiosensitization  Lee J, Karshafian R, Papanicolau N, Giles A, Kolios MC, Czarnota GJ. (2012) 
Ultrasound in Medicine and Biology Volume 38, Issue 7, Pages 1212–1221
  1. . Classification of the nonlinear dynamics and bifurcation structure of ultrasound contrast agents excited at higher multiples of their resonance frequency Amin Jafari Sojahrood and Michael C. Kolios (2012) 
Physics Letters A, Volume 376, Issue 33 pp. 2222–2229
  1. . Validity of a theoretical model to examine blood oxygenation dependent optoacoustics  Ratan K. Saha, Subhajit Karmakar, Eno Hysi, Madhusudan Roy, and Michael C. Kolios (2012) Journal of Biomedical Optics 17(5), 055002
  1. . Feasibility of optical coherence elastography measurements of shear wave propagation in homogeneous tissue equivalent phantoms  Marjan Razani, Adrian Mariampillai, Cuiru Sun, Timothy W. H. Luk, Victor X. D. Yang, and Michael C. Kolios (2012)
    Biomedical Optics Express, Vol. 3, Issue 5, pp. 972-980


  1. Effects of erythrocyte oxygenation on optoacoustic signals Ratan K. Saha and Michael C. Kolios (2011), Journal of Biomedical Optics 16, 115003; doi:10.1117/1.3655355
  1. Detecting apoptosis using dynamic light scattering with optical coherence tomography Golnaz Farhat, Adrian Mariampillai, Victor X. D. Yang, Gregory J. Czarnota and Michael C. Kolios (2011), Journal of Biomedical Optics 16, 070505 (Jul 18, 2011); doi:10.1117/1.3600770
  1. Effects of Cell Spatial Organization and Size Distribution on Ultrasound Backscattering  Ratan K. Saha and Michael C. Kolios (2011) IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control, vol.58(10)  2118-2131
  1. A simulation study on photoacoustic signals from red blood cells   Ratan K. Saha and Michael C. Kolios (2011) The Journal of the Acoustical Society of America 129 (5)  – 2935–2943
  1. Vaporization of perfluorocarbon droplets using optical irradiation   Eric Strohm, Min Rui, Ivan Gorelikov, Naomi Matsuura, and Michael Kolios (2011) Biomedical Optics Express, Vol. 2, Issue 6, pp. 1432-1442
  1. Detecting cell death with optical coherence tomography and envelope statistics    Golnaz Farhat, Victor X. D. Yang, Gregory J. Czarnota and Michael C. Kolios (2011) Journal of Biomedical Optics 16(2) – 026017
  1. Hybrid Quantum Dot−Fatty Ester Stealth Nanoparticles: Toward Clinically Relevant in Vivo Optical Imaging of Deep TissueAdam J. Shuhendler, Preethy Prasad, Ho-Ka Carol Cha†, Claudia R. Gordijo, Behrouz Soroushian, Michael Kolios, Kui Yu, Peter J. O’Brien, Andrew Michael Rauth, and Xiao Yu Wu (2011) ACS Nano 5(3) – 1958-1966


  1. Vlad RM, Kolios MC, Moseley JL, Czarnota GJ, Brock KK. Evaluating the extent of cell death in 3D high frequency ultrasound by registration with whole-mount tumor histopathology. Med Phys. 2010 Aug;37(8):4288-97. PubMed PMID: 20879589.
  1. Vlad RM, Saha RK, Alajez NM, Ranieri S, Czarnota GJ, Kolios MC. An increase in cellular size variance contributes to the increase in ultrasound backscatter during cell death. Ultrasound Med Biol. 2010 Sep;36(9):1546-58. DOI: 10.1016/j.ultrasmedbio.2010.05.025. PubMed PMID: 20800181.
  1. Park JI, Jagadeesan D, Williams R, Oakden W, Chung S, Stanisz GJ, Kumacheva E. Microbubbles loaded with nanoparticles: a route to multiple imaging modalities. ACS Nano. 2010 Nov 23;4(11):6579-86. doi: 10.1021/nn102248g. Epub 2010 Oct 18. PubMed PMID: 20968309.

  1. . Quantitative measurements of apoptotic cell properties using acoustic microscopy E. Strohm, G. J. Czarnota, and M. C. Kolios, IEEE transactions on ultrasonics, ferroelectrics, and frequency control, vol. 57, no. 10, pp. 2293–304, Oct. 2010.
  1. . An increase in cellular size variance contributes to the increase in ultrasound backscatter during cell death R. M. Vlad, R. K. Saha, N. M. Alajez, S. Ranieri, G. J. Czarnota, and M. C. Kolios, Ultrasound in medicine & biology, vol. 36, no. 9, pp. 1546–58, Sep. 2010.
  1. . Functional imaging using diffuse optical spectroscopy of neoadjuvant chemotherapy response in women with locally advanced breast cancer H. Soliman, A. Gunasekara, M. Rycroft, J. Zubovits, R. Dent, J. Spayne, M. J. Yaffe, and G. J. Czarnota, Clinical cancer research : an official journal of the American Association for Cancer Research, vol. 16, no. 9, pp. 2605–14, May 2010.
  1. . Imaging breast cancer chemotherapy response with light: Commentary on Soliman et al. B. J. Tromberg and A. E. Cerussi, Clinical cancer research : an official journal of the American Association for Cancer Research, vol. 16, no. 9, pp. 2486–8, May 2010.
  1. . Ultrasound detection of cell death G. J. Czarnota and M. C. Kolios, Imaging in Medicine, vol. 2, no. 1, pp. 17–28, Feb. 2010.
  1. . Study of laser-induced thermoelastic deformation of native and coagulated ex-vivo bovine liver tissues for estimating their optical and thermomechanical properties Behrouz Soroushian, William M. Whelan, Michael C. Kolios (2010)
    Journal of Biomedical Optics 15(6) – 065002
  1. . Quantitative Measurements of Apoptotic Cell Properties Using Acoustic Microscopy   Eric M. Strohm, Gregory J. Czarnota, and Michael C. Kolios (2010), IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control, vol. 57, no. 10
  1. . An increase in cellular size variance contributes to the increase in ultrasound backscatter during cell death    Roxana M. Vlad, Ratan K Saha, Nehad M. Alajez, Shawn Ranieri, Gregory J. Czarnota and Michael C. Kolios (2010), Ultrasound in Medicine and Biology 36 (9) 1546-1558
  1. . The measurement of ultrasound scattering from individual micron-sized objects and its application in single cell scattering   Omar Falou, Min Rui, Ahmed El Kaffas,  J. Carl Kumaradas and Michael C. Kolios (2010), The Journal of the Acoustical Society of America 128 (2) 894–902
  1. . Evaluating the extent of cell death in 3D high frequency ultrasound by registration with whole-mount tumor histopathologyRoxana M. Vlad, Michael C. Kolios, Joanne L. Moseley, Gregory J. Czarnota, Kristy K. Brock (2010)
    Medical Physics 37 (8) 4288-4297
  1. . Single cell size estimation from backscattered spectrum by using some weak acoustic scattering approximationsRatan K Saha, Subodh K Sharma and Michael C Kolios (2010) Canadian Acoustics / Acoustique canadienne 38 (2) 31-34
  1. . Ultrasound detection of cell deathGregory J. Czarnota and Michael C. Kolios (2010) Imaging in Medicine 2(1) 17-28


  1. Bailey C, Giles A, Czarnota GJ, Stanisz GJ. Detection of apoptotic cell death in vitro in the presence of Gd-DTPA-BMA. Magn Reson Med. 2009 Jul;62(1):46-55. doi: 10.1002/mrm.21972. PubMed PMID: 19253383.
  1. Dinniwell R, Chan P, Czarnota G, Haider MA, Jhaveri K, Jewett M, Fyles A, Jaffray D, Milosevic M. Pelvic lymph node topography for radiotherapy treatment planning from ferumoxtran-10 contrast-enhanced magnetic resonance imaging. Int J Radiat Oncol Biol Phys. 2009 Jul 1;74(3):844-51. doi:10.1016/j.ijrobp.2008.09.026. Epub 2008 Dec 25. PubMed PMID: 19095369.
  1. Strohm EM, Kolios MC. Measuring the mechanical properties of cells using acoustic microscopy. Conf Proc IEEE Eng Med Biol Soc. 2009;2009:6042-5. doi:10.1109/IEMBS.2009.5334535. PubMed PMID: 19964888.
  1. Bost W, Stracke F, Weiss EC, Narasimhan S, Kolios MC, Lemor R. High frequency optoacoustic microscopy. Conf Proc IEEE Eng Med Biol Soc. 2009;2009:5883-6. doi:10.1109/IEMBS.2009.5334452. PubMed PMID: 19964880.
  1. Smith SA, Golay X, Fatemi A, Mahmood A, Raymond GV, Moser HW, van Zijl PC, Stanisz GJ. Quantitative magnetization transfer characteristics of the human cervical spinal cord in vivo: application to adrenomyeloneuropathy. Magn Reson Med. 2009 Jan;61(1):22-7. doi: 10.1002/mrm.21827. PubMed PMID: 19097204; PubMed Central PMCID: PMC2632947.
  1. Shepherd TM, Thelwall PE, Stanisz GJ, Blackband SJ. Aldehyde fixative solutions alter the water relaxation and diffusion properties of nervous tissue. Magn Reson Med. 2009 Jul;62(1):26-34. doi: 10.1002/mrm.21977. PubMed PMID: 19353660; PubMed Central PMCID: PMC3188415.
  1. Shepherd TM, Flint JJ, Thelwall PE, Stanisz GJ, Mareci TH, Yachnis AT, Blackband SJ. Postmortem interval alters the water relaxation and diffusion properties of rat nervous tissue–implications for MRI studies of human autopsy samples. Neuroimage. 2009 Feb 1;44(3):820-6. doi: 10.1016/j.neuroimage.2008.09.054. Epub 2008 Oct 19. PubMed PMID: 18996206; PubMed Central PMCID: PMC2836859.

  1. Potential use of ultrasound for the detection of cell changes in cancer treatment   Michael C. Kolios and Gregory J. Czarnota (2009)
    Future Oncology 5(10) 1527-1532
  1. Quantitative Ultrasound Characterization of Responses to Radiotherapy in Cancer Mouse Models    Vlad RM, Brand S, Giles A, Kolios MC, Czarnota GJ. (2009) Clincal Cancer Research 15(6):2067-75
  1. Monitoring of cell death in epithelial cells using high frequency ultrasound spectroscopy   Brand S, Solanki B, Foster DB, Czarnota GJ, Kolios MC. (2009) Ultrasound in Medicine and Biology 35(3):482-93


  1. Banihashemi B, Vlad R, Debeljevic B, Giles A, Kolios MC, Czarnota GJ. Ultrasound imaging of apoptosis in tumor response: novel preclinical monitoring of photodynamic therapy effects. Cancer Res. 2008 Oct 15;68(20):8590-6. doi:10.1158/0008-5472.CAN-08-0006. PubMed PMID: 18922935.
  1. Yu WR, Baptiste DC, Liu T, Odrobina E, Stanisz GJ, Fehlings MG. Molecular mechanisms of spinal cord dysfunction and cell death in the spinal hyperostotic mouse: implications for the pathophysiology of human cervical spondylotic myelopathy. Neurobiol Dis. 2009 Feb;33(2):149-63. doi: 10.1016/j.nbd.2008.09.024. Epub 2008 Oct 18. PubMed PMID: 19006686.
  1. Buckley DL, Kershaw LE, Stanisz GJ. Cellular-interstitial water exchange and its effect on the determination of contrast agent concentration in vivo: dynamic contrast-enhanced MRI of human internal obturator muscle. Magn Reson Med. 2008 Nov;60(5):1011-9. doi: 10.1002/mrm.21748. PubMed PMID: 18956419.

  1. Quantitative Ultrasound Characterization of Cancer Radiotherapy Effects In Vitro Roxana M. Vlad, Nehad M. Alajez, Anoja Giles, Michael C. Kolios, Gregory J. Czarnota (2008) International Journal of Radiation Oncology Biology Physics, 72 (4): 1236-1243
  1. A study of high frequency ultrasound scattering from non-nucleated biological specimens  Omar Falou, Ralph E. BaddourGeorge Nathanael, Gregory J. Czarnota, J. Carl Kumaradas and Michael C. Kolios (2008), The Journal of the Acoustical Society of America 124(5): EL278-EL283
  1. Detecting the Effects of Photodynamic Therapy in vivo by High Frequency Ultrasound Spectroscopy: a Novel Way of Monitoring Tumour Response  Behzad Banihashemi, Roxana VladBane Debeljevic, Anoja Giles, Michael C. Kolios, Gregory J. Czarnota (2008)
    Cancer Research 68(20): 8590-8596
  1. High frequency ultrasound tissue characterization and acoustic microscopy of intracellular changes Sebastian Brand, Weiss EC, Lemor RM, and Kolios M.C. (2008), Ultrasound in Medicine and Biology 34(9): 1396-1407


  1. Portnoy S, Stanisz GJ. Modeling pulsed magnetization transfer. Magn Reson Med. 2007 Jul;58(1):144-55. PubMed PMID: 17659607.

  1. Parametric analysis of ultrasound backscatter signals for monitoring cancer cell structural changes during cancer treatment  Harshitha Nallapareddy, Sridhar Krishnan and Michael Kolios (2007) Canadian Acoustics 35(2): 47-54
  1. High-Frequency Ultrasound Assessment of Antimicrobial Photodynamic Therapy In Vitro Ralph E. Baddour, Farhan N. Dadani, Michael C. Kolios and Stuart K. Bisland (2007) Journal of Biological Physics 33:61–66
  1. Ultrasonic Characterization of Whole Cells and Isolated Nuclei,   Linda Taggart, Ralph E. Baddour, Anoja Giles, Gregory J. Czarnota and Michael C. Kolios (2007) Ultrasound in Medicine and Biology 33 (3): 389-401
  1. Wide dynamic range detection of bidirectional flow in Doppler optical coherence tomography using a two-dimensional Kasai estimator  Darren Morofke, Michael C. Kolios, I. Alex Vitkin and Victor X. D. Yang (2007) Optics Letters 32 (3): 253-255
  1. The fluid and elastic nature of nucleated cells: Implications from the cellular backscatter response  Ralph E. Baddour and Michael C. Kolios (2007), JASA Express Letters 121 (1): 16-22


  1. Thelwall PE, Shepherd TM, Stanisz GJ, Blackband SJ. Effects of temperature and aldehyde fixation on tissue water diffusion properties, studied in an erythrocyte ghost tissue model. Magn Reson Med. 2006 Aug;56(2):282-9. PubMed PMID: 16841346.
  1. Bower JA, Stanisz GJ, Keir PJ. An MRI evaluation of carpal tunnel dimensions in healthy wrists: Implications for carpal tunnel syndrome. Clin Biomech (Bristol, Avon). 2006 Oct;21(8):816-25. Epub 2006 Jul 11. PubMed PMID: 16814908.

  1. An Investigation of the Use of Transmission Ultrasound to Measure Acoustic Attenuation Changes in Thermal Therapy Parmar N. and Kolios M.C. (2006) Medical and Biological Engineering and Computing 44:583-591


  1. Taggart LR, Baddour RE, Giles A, Czarnota GJ, Kolios MC. Ultrasonic characterization of whole cells and isolated nuclei. Ultrasound Med Biol. 2007 Mar;33(3):389-401. PubMed PMID: 17257739.
  1. Shepherd TM, Scheffler B, King MA, Stanisz GJ, Steindler DA, Blackband SJ. MR microscopy of rat hippocampal slice cultures: a novel model for studying cellular processes and chronic perturbations to tissue microstructure. Neuroimage. 2006 Apr 15;30(3):780-6. Epub 2005 Dec 1. PubMed PMID: 16325430.
  1. Stanisz GJ, Odrobina EE, Pun J, Escaravage M, Graham SJ, Bronskill MJ, Henkelman RM. T1, T2 relaxation and magnetization transfer in tissue at 3T. Magn Reson Med. 2005 Sep;54(3):507-12. PubMed PMID: 16086319.
  1. Pun TW, Odrobina E, Xu QG, Lam TY, Munro CA, Midha R, Stanisz GJ. Histological and magnetic resonance analysis of sciatic nerves in the tellurium model of neuropathy. J Peripher Nerv Syst. 2005 Mar;10(1):38-46. PubMed PMID:15703017.
  1. Odrobina EE, Lam TY, Pun T, Midha R, Stanisz GJ. MR properties of excised neural tissue following experimentally induced demyelination. NMR Biomed. 2005 Aug;18(5):277-84. PubMed PMID: 15948233

  1. Monitoring Structural Changes in Cells with High Frequency Ultrasound Signal Statistics   A.S. Tunis G.J. Czarnota, A. Giles, M.D. Sherar, J.W. Hunt and M.C. Kolios (2005) , Ultrasound in Medicine and Biology 31(8), 1041-10
  1. High-frequency ultrasound scattering from microspheres and single cells  R. E. Baddour, M. D. Sherar, J. W. Hunt, G. J. Czarnota, M. C. Kolios (2005), Journal of  the Acoustical Society of  America, 117(2), 934-943

  1. High-frequency ultrasound for monitoring changes in liver tissue during preservation  Roxana M. Vlad, Gregory J. Czarnota, Anoja Giles, Michael D. Sherar, John W. Hunt, Michael C. Kolios (2005), Physics in Medicine and Biology, 50(2) 197-213
  1. Role of ultrasound in the detection of apoptosis G. J. Czarnota, European journal of nuclear medicine and molecular imaging, vol. 32, no. 5, p. 622, May 2005.


  1. Stanisz GJ, Webb S, Munro CA, Pun T, Midha R. MR properties of excised neural tissue following experimentally induced inflammation. Magn Reson Med. 2004 Mar;51(3):473-9. PubMed PMID: 15004787.


  1. Thelwall PE, Grant SC, Stanisz GJ, Blackband SJ. Human erythrocyte ghosts: exploring the origins of multiexponential water diffusion in a model biological tissue with magnetic resonance. Magn Reson Med. 2002 Oct;48(4):649-57. PubMed PMID: 12353282.
  1. Stanisz GJ, Yoon RS, Joy ML, Henkelman RM. Why does MTR change with neuronal depolarization? Magn Reson Med. 2002 Mar;47(3):472-5. PubMed PMID: 11870833.

  1. Webb S, Munro CA, Midha R, Stanisz GJ. Is multicomponent T2 a good measure of myelin content in peripheral nerve? Magn Reson Med. 2003 Apr;49(4):638-45. PubMed PMID: 12652534.

  1. Changes in dielectric properties at 460 kHz of kidney and fat during heating: importance for radio-frequency thermal therapy Mihaela Pop, Andrea Molckovsky, Lee Chin, Michael C Kolios, Michael A S Jewett and Michael D Sherar (2003) Physics in Medicine and Biology 48, 2509-2525


1. Ultrasonic spectral parameter imaging of apoptosis   Kolios M.C., Czarnota G.J., Lee M. , Hunt J.W. and Sherar M.D. (2002)
Ultrasound in Medicine and Biology 28(5), 589-597
2. A model based upon pseudo-regular spacing of cells combined with the randomization of nuclei can explain the significant changes in high-frequency ultrasound during apoptosis Hunt J.W., Worthington A., Xuan A., Kolios M.C., Czarnota G.J. and Sherar M.D. (2002) Ultrasound in Medicine and Biology 28(2), 217-226


1. Comparison of thermal damage calculated using magnetic resonance thermometry with magnetic resonance imaging post treatment and histology after interstitial microwave thermal therapy of rabbit brain M. D Sherar, J. A. Moriarty, M.C. Kolios, J.C. Chen, R.D. Peters, L.C. Ang, R.S. Hinks, R.M. Henkelman, M.J. Bronskill, W. Kucharczyk (2000)
Physics in Medicine and Biology 45, 3563-3576
2. The Effects of Dynamic Optical Properties During Interstitial Laser PhotocoagulationIizuka M.N., Vitkin A.I., Kolios M.C., Sherar M.D. (2000)
Physics in Medicine and Biology 45, 1335-1357


1. Ultrasound imaging of apoptosis: high-resolution non-invasive imaging of programmed cell death in vitro, in situ and in vivo Czarnota G.J., Kolios M.C., Abraham J., Portnoy M., Ottensmeyer F.P., Hunt, J.W. and Sherar M.D.British journal of cancer, vol. 81, no. 3, pp. 520–527, (1999)

2. An investigation of the flow dependence of temperature gradients near large vessel during steady state and transient tissue heating Kolios M.C., Worthington A.E., Holdsworth D.W., Sherar M.D. and Hunt J.W. (1999) Physics in Medicine and Biology 44(6), 1479-1497


1. A Theoretical Comparison of Energy Sources: Microwave, Ultrasound and Laser, for Interstitial Thermal Therapy Skinner M., Iizuka M., Kolios M.C. and Sherar M.D. (1998) Physics in Medicine and Biology 43(12), 3535-3547

2. Experimental evaluation of two simple thermal models using transient temperature analysis Kolios M.C., Worthington A. E., Sherar M.D. and Hunt J.W. (1998) Physics in Medicine and Biology 43(11), 3325-3340


1. Ultrasonic biomicroscopy of viable, dead and apoptotic cells Czarnota G.J.* , Kolios M.C.* , Vaziri H.* , Benchimol S., Ottensmeyer F.P., Sherar M.D. and Hunt J.W. (1997) Ultrasound in Medicine and Biology 23(6), 961-965 * authors have made equal contribution
2. Magnetic resonance imaging of temperature changes during interstitial microwave heating: a phantom study Vitkin I.A., Moriarty J.A., Peters R.D., Kolios M.C., Gladman A.S., Chen J.C., Hinks R.S., Hunt J.W., Wilson B.C., Easty A.T., Bronskill M.J., Kucharczyk W., Sherar M.D. and Henkelman R.M. (1997) Medical Physics 24, 269-277

3. Three-dimensional Structure of Myelin Basic Protein D. R. Beniac, M. D. Luckevich, G. J. Czarnota, T. A. Tompkins, R. A. Ridsdale, F. P. Ottensmeyer, M. A. Moscarello, and G. Harauz, vol. 272, no. 7, pp. 4261–4268, 1997.

4. High Resolution Microanalysis and Three-Dimensional Nucleosome Structure Associated with Transcribing Chromatin G. J. Czarnota, D. P. Bazett-Jones, E. Mendez, V. G. Allfrey, and F. P. Ottensmeyer, Micron, vol. 28, no. 419–431, p. 1997, 1997.


1- Blood flow cooling and ultrasonic lesion formation Kolios M.C., Sherar M.D. and Hunt J.W. (1996) Medical Physics 23(7), 1287-98

2- Structural states of the nucleosome G. J. Czarnota and F. P. Ottensmeyer, The Journal of biological chemistry, vol. 271, no. 7, pp. 3677–83, Feb. 1996.

3- Visualization and analysis of unfolded nucleosomes associated with transcribing chromatin D. P. Bazett-Jones, E. Mendez, G. J. Czarnota, F. P. Ottensmeyer, and V. G. Allfrey, Nucleic acids research, vol. 24, no. 2, pp. 321–9, Jan. 1996.


1- Large vessel cooling in heated tissues: a numerical study Kolios M.C., Sherar M.D. and Hunt J.W. (1995) Physics in Medicine and Biology 40, 1-18

2- A Structure for the Signal Sequence Binding Protein SRP54: 3D Reconstruction from STEM Images of Single Molecules G. J. Czarnota, D. W. Andrews, N. A. Farrow, and F. P. Ottensmeyer, “” Journal of Structural Biology, vol. 113, pp. 35–46, 1994.


1- Influence of transition rates and scan rate on kinetic simulations of differential scanning calorimetry profiles of reversible and irreversible protein denaturation Lepock J.R., Ritchie K.P., Kolios M.C., Rodahl A.M., Heinz K.A., and Kruuv J. (1992)
Biochemistry 31(50), 12706-12

Book Chapters

Book Chapters

Gangeh MJ, Tadayyon H, Tran WT, and Czarnota GJ, Machine Learning Applications in Cancer Therapy Assessment and Implications on Clinical Practice, In: B.H. Far (ed.), Handbook of Research on Data Science for Effective Healthcare Practice and Administration, IGI Global, 2016.

Tadayyon H, Gangeh MJ, Vlad R, Kolios MC, and Czarnota GJ, Ultrasound Imaging of Apoptosis: Spectroscopic Detection of DNA-Damage Effects In Vivo, In: V. Didenko (ed.), Express Detection of DNA damage: Methods and Protocols, Springer Protocols, 2016 (To Appear).

Tadayyon H, Gangeh MJ, Vlad R, Kolios MC, and Czarnota GJ, Ultrasound Imaging of DNADamage Effects in Live Cultured Cells and in Brain Tissue, In: V. Didenko (ed.), Express Detection of DNA damage: Methods and Protocols, Springer Protocols, 2016 (To Appear).

1- Ultraosund Contrast Microbubbles: In vivo Imaging and Potential Therapeutic Applications
A. Caissie, R. Karshafian, K. Hynynen, and G. J. Czarnota (2012)
Nanoimaging, 2011, pp. 1–25.
Edited by: Beth Goins and William Phillips © Pan Stanford Publishing Pte. Ltd.

2- Ultrasound imaging of apoptosis: spectroscopic detection of DNA-damage effects at high and low frequencies.
Vlad RM, Kolios MC, Czarnota GJ. (2011)
Methods in Molecular Biology Volume 682, Part 3, 165-187
Edited by: V. V. Didenko © Humana Press Inc., Totowa, NJ

3- Ultrasound Imaging of Apoptosis: DNA Damage Visualized
Czarnota, G.J. Kolios, M.C. Hunt, J.W. and Sherar, M.D (2002)
in Methods in Molecular Biology, vol. 203: In Situ Detection of DNA Damage: Methods and Protocols Edited by: V. V. Didenko © Humana Press Inc., Totowa, NJ

Conference Papers ( Peer Reviewed )

1- Temperature Dependent Properties and Ultrasound Thermal Therapy
Kolios M.C., Sherar M.D. and Hunt J.W. (1999)
In E.P. Scott (Ed.) Advances in Heat and Mass Transfer in Biotechnology
HTD-Vol.363 / BED- Vol.44, 113-118. American Society of Mechanical Engineers.

2- The Effect of Heat Induced Changes in Microwave Tissue Properties on Thermal Therapy for Prostate Cancer
Sherar M.D., Chin, L. Kolios M.C. and Gladman, A.S. (1999)
In E.P. Scott (Ed.) Advances in Heat and Mass Transfer in Biotechnology HTD-Vol.363 / BED-Vol.34, 109-112. American Society of Mechanical Engineers.

3- Monitoring tissue response to photodynamic therapy: The potential of minimally invasive electrical impedance spectroscopy and high frequency ultrasound
Wilson B.C., Molckovsky A., Czarnota G.J., Sherar M.D., Kolios M.C. Lilge, L. Dattani R.S., Osterman K.S., Paulsen K.D., Hoopes P.J. (1999)
In S.L. Jacques (Ed.) Proceedings of the 1999 SPIE, Vol. 3592 , 73-82.

4- Thermal model predictions of ultrasonic lesion formation
Kolios M.C., Sherar M.D. and Hunt J.W. (1995)
In L.J. Hayes (Ed.), Advances in Bioheat and Mass Transfer in Biotechnology , HTD-Vol.322 / BED-Vol.32, 139-144. American Society of Mechanical Engineers.

5- Modeling temperature gradients near large vessels in perfused tissues
Kolios, M.C. Sherar, M.D Worthington, A. E. and Hunt, J.W. (1994)
In M. Ebadian and P. Oosthuizen (Eds.), Fundamentals of Biomedical Heat Transfer, HTD-Vol. 295, 23-30. American Society of Mechanical Engineers.

Conference Papers ( Non Peer Reviewed )

2011 | 2001 | 1997 | 1996


  1. Farhat G, Yang VX, Czarnota GJ, Kolios MC. Detecting cell death with optical coherence tomography and envelope statistics. J Biomed Opt. 2011 Feb;16(2):026017. DOI: 10.1117/1.3544543. PubMed PMID: 21361701.
  1. Farhat G, Mariampillai A, Yang VX, Czarnota GJ, Kolios MC. Detecting apoptosis using dynamic light scattering with optical coherence tomography. J Biomed Opt. 2011 Jul;16(7):070505. DOI: 10.1117/1.3600770. PubMed PMID: 21806246.
  1. Bailey C, Desmond KL, Czarnota GJ, Stanisz GJ. Quantitative magnetization transfer studies of apoptotic cell death. Magn Reson Med. 2011 Jul;66(1):264-9. doi: 10.1002/mrm.22820. Epub 2011 Feb 17. PubMed PMID: 21695728.


1- Analysis of Ultrasound Backscatter from Ensembles of Cells and Isolated Nuclei  M.C. Kolios, G.J. Czarnota, M. Hussain, F. S. Foster, J.W. Hunt and M.D. Sherar (2001) In Proceedings of the 2001 IEEE International Ultrasonics Symposium


1- New Acoustic Beams Designed for Rapid Lesion Formation: Limitations Near the Skin During Multiple Lesion Treatments
J.W. Hunt, A.Y. Xuan, E. Seto, A.W. Worthington, L. Chen, M.C. Kolios , and Sherar M.D. (1997) In Proceedings of the 1997 IEEE International Ultrasonics Symposium

2- Spatial Correlation of Flow Induced Temperature Gradients During Tissue Heating with Vascular Geometry using CT Angiography: Implications for Thermal Therapy Kolios, M.C. Sherar, M.D, Worthington, A. E., Holdsworth, D.W. and Hunt, J.W. (1997)
In Proceedings of the Canadian Organization of Medical Physicists (1997), p. 149-151 (abstract also published in Medical Physics (24)1206, 1997)


  1. Correlation of steady state and transient temperature profiles in perfused fixed kidneys: implications for thermal models. 

Kolios, M.C. Sherar, M.D, Worthington, A. E. and Hunt, J.W. (1996) In C. Franconi, G. Archangeli and R. Cavaliere (Eds.), Hyperthermic Oncology 1996, 509-511.

Posters ( Non Peer Reviewed )

  1. High frequency ultrasound monitoring of structural changes in cells and tissue Tunis, A. Giles, A. McAdulff, D. Spurrell, D. Hariri, M. Khokha, R. Hunt, J. Czarnota, G. Sherar, M. and Kolios, M.C.
  2. High frequency ultrasound in monitoring organ viability for transplantation Vlad, R. Giles, A. Czarnota, G. Hunt, J. Sherar, M. and Kolios, M.C