Research

  • Research Summary

    Radiation and chemotherapy remain foundational elements of cancer care for cancer patients. Our focus is on making chemotherapy and radiation therapy, two of the most common cancer treatments, significantly better. We are working towards developing personalized cancer care though the development of new innovative ultrasound and MRI imaging methods which can be used to tell

  • Quantitative Ultrasound For Chemotherapy Enhancement

    The overarching goal of this research is to transform conventional ultrasound, which is non-invasive, inexpensive and portable, such that it can be used to quantitatively to assess breast cancer therapies through functional imaging, in which tumour cell death is detected. By detecting cell death early in a treatment (within hours to days), rather than traditional

  • Photoacoustics

    Subproject 1: PA monitoring of treatment progression This aspect of the grant has been focusing on using PA imaging to monitor the progression of cancer treatments. We are particularly interested in monitoring the vascular changes that occur very early (within hours) after the administration of treatment. In the first 12 months of the grant, the

  • Microbubble Therapy For Radiation Enhancement

    We have recently discovered that ultrasound activated microbubbles may be used to enhance the effects of radiation. In this novel application, pretreating tumour vasculature to biophysically perturb endothelial cells enhances the effects of radiation by more than 10-fold. Exposure of endothelial cells to ultrasound stimulated microbubbles, given intravenously, causes vascular destruction, further enhanced by combining

  • Magnetic Resonance Imaging for Cancer Imaging and Therapy Response

    In the last five years we have worked on three sub-projects directly related to this component: Development of new, more specific MRI contrast agents for cancer diagnostic. Improvements and optimization of the MRI sequences for more robust and accurate quantitative imaging of cancer. Development of novel MRI sequences for early detection of the processes of